Female Endocrine Modulation in PTSD

Project Overview

This research investigates the complex relationship between female endocrine function (e.g., menstrual cycle phases, hormonal contraceptives) and Post-Traumatic Stress Disorder (PTSD) symptoms. We explore how fluctuations in hormones like estrogen and progesterone may influence symptom severity, fear learning processes, and treatment response in women with PTSD.

Key Research Questions

• How do specific phases of the menstrual cycle influence PTSD symptom expression (e.g., intrusive thoughts, hypervigilance)?
• What is the role of reproductive hormones (estrogen, progesterone) in modulating fear learning, extinction, and memory consolidation relevant to PTSD?
• Does endocrine status (e.g., natural cycling, hormonal contraceptive use) affect outcomes in PTSD treatments like exposure therapy?
• Can timing interventions based on hormonal cycles potentially improve therapeutic efficacy for women with PTSD?

Methodology

Our research combines careful endocrine assessments (hormone assays, cycle tracking) with neuroimaging (fMRI during fear conditioning tasks), psychophysiological measures (skin conductance), and detailed clinical/symptom assessments. Longitudinal monitoring allows us to track relationships between hormonal fluctuations and PTSD-related variables over time.

Current Status

Initial findings suggest significant interactions between endocrine function (particularly menstrual cycle phase) and PTSD symptomatology, as well as fear learning processes. We are currently investigating how these relationships might inform the timing and type of interventions for female patients with PTSD, aiming to contribute to sex-specific treatment approaches.