PTSD Subtypes and Neural Biomarkers

Project Overview

This systematic review aims to synthesize the existing literature on Post-Traumatic Stress Disorder (PTSD) subtypes and their corresponding neural biomarkers. By critically evaluating studies that use neuroimaging and other biological measures to differentiate PTSD subgroups (e.g., dissociative subtype, high-anxiety subtype), we aim to provide a comprehensive overview of the current state of knowledge and identify gaps for future research.

Key Research Questions

• What are the most consistently identified PTSD subtypes based on clinical and biological data?
• What specific neural biomarkers (structural, functional, connectivity) distinguish these subtypes?
• How reliable and replicable are the findings across different studies and populations?
• What are the implications of these findings for personalized diagnosis and treatment of PTSD?

Methodology

We conduct a comprehensive search of scientific databases (e.g., PubMed, PsycINFO, Web of Science) using predefined keywords related to PTSD, subtypes, neuroimaging, and biomarkers. Studies meeting inclusion criteria are systematically reviewed, extracted, and synthesized to identify consistent patterns and discrepancies in the literature.

Current Status

The systematic review process is underway. We are currently screening articles and extracting data from eligible studies. The final synthesis will highlight key findings, limitations of existing research, and propose directions for future investigations into PTSD heterogeneity.